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KMID : 0545120100200111521
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Journal of Microbiology and Biotechnology
2010 Volume.20 No. 11 p.1521 ~ p.1523
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Isolation and Structure Determination of a Cholesterol Esterase Inhibitor from Ganoderma lucidum
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Kim Shin-Duk
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Abstract
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Bioassay-guided fractionation of methanol extract of Ganoderma lucidum gave a pure cholesterol esterase inhibitor. On the basis of spectroscopic analysis and comparison with data from the literature, its structure was identified as 5α,8α-epidioxyergosta-6,22-dien-3β-ol (compound I). Compound (I) inhibited cholesterol esterase with an IC50 value of 42 μM. A Lineweaver-Burk plot revealed that the compound (I) is a noncompetitive inhibitor. Findings from this study suggest that compound (I) may be the active principle of the hypocholesterolemic effect of Ganoderma lucidum.
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KEYWORD
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Ganoderma lucidum, ergosterol peroxide, cholesterol esterase inhibitor, hypocholesterolemic effect
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